A Mutation within the Extended X Loop Abolished Substrate-induced ATPase Activity of the Human Liver ATP-binding Cassette (ABC) Transporter MDR3

A generic protein purification method for protein complex characterization and proteome exploration

Guillaume Rigaut, Anna Shevchenko, Berthold Rutz et al. · Nature Biotechnology · 1999 · 2.7K citations

Proteomic Technology, Biochemistry, Protein Folding +10

Structure of P-Glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding

Stephen G. Aller, Jodie Yu, Andrew B. Ward et al. · Science · 2009 · 1.9K citations · Full text

Drug Target, Glycobiology, P-glycoprotein Reveals +19

Homozygous disruption of the murine MDR2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease

Jasper Smit, Alfred H. Schinkel, Ronald P.J. Oude Elferink et al. · Cell · 1993 · 1.5K citations

Hepatology, Biochemistry, Biliary Tract +11

Structure of a bacterial multidrug ABC transporter

Roger Dawson, Kaspar P. Locher · Nature · 2006 · 1.3K citations

Antibiotics, Bacteriology, Microbiology +4

Expression of a full-length cDNA for the human "MDR1" gene confers resistance to colchicine, doxorubicin, and vinblastine.

Kazumitsu Ueda, Carol Cardarelli, Michael M. Gottesman et al. · Proceedings of the National Academy of Sciences · 1987 · 1.1K citations · Full text

Full-length Cdna, Immunology, Molecular Biology +16