Concepedia

Publication | Closed Access

The role of active metabolites in dihydrocodeine effects

DOI

53

Citations

0

References

2003

Year

Harald Schmidt, Stefan Viktor Vormfelde, Monika Walchner‐Bonjean, Klaus Klinder, Stefan Freudenthaler, C. H. Gleiter, Ursula Gundert‐Remy, Gisela Skopp, R. Aderjan, Uwe Fuhr
International Journal of Clinical Pharmacology and Therapeutics

Abstract

CYP2D6 phenotype has no major impact on opioid receptor-mediated effects of a single 60 mg dihydrocodeine dose, despite the essential role of CYP2D6 in formation of highly active metabolites.