Concepedia

Intercellular nanovesicle-mediated microRNA transfer: A mechanism of environmental modulation of hepatocellular cancer cell growth

Takayuki Kogure, Wen-Lang Lin, Irene K. Yan, Chiara Braconi, Tushar Patel

Hepatology · 2011 · 528 citations · 21 references

DOIFull text

Open access

Abstract

Exosome-mediated miRNA transfer is an important mechanism of intercellular communication in HCC cells. These observations identify a unique intercellular mechanism that could potentially contribute to local spread, intrahepatic metastases, or multifocal growth in HCC.

References

21

Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells

Hadi Valadi, Karin M. Ekström, Apostolos Bossios et al. · Nature Cell Biology · 2007 · 12.6K citations

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Isolation and Characterization of Exosomes from Cell Culture Supernatants and Biological Fluids

Clotilde Théry, Sebastián Amigorena, Graça Raposo et al. · Current Protocols in Cell Biology · 2006 · 5.7K citations

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Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers

Johan Skog, Tom Würdinger, Sjoerd van Rijn et al. · Nature Cell Biology · 2008 · 4.9K citations

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STRING 8--a global view on proteins and their functional interactions in 630 organisms

Lars Juhl Jensen, Michael Kuhn, Mitchell Stark et al. · Nucleic Acids Research · 2008 · 2.5K citations · Full text

Eradication of established murine tumors using a novel cell-free vaccine: dendritic cell derived exosomes

Laurence Zitvogel, Armelle Régnault, Anne Lozier et al. · Nature Medicine · 1998 · 2.2K citations

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