Impaired microvascular perfusion in sepsis requires activated coagulation and P-selectin-mediated platelet adhesion in capillaries

Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood

Stephen Clark, C. Adrienne, Samantha A. Tavener et al. · Nature Medicine · 2007 · 2.3K citations

Life Sciences, Immunology, Microbiology +16

Persistent microcirculatory alterations are associated with organ failure and death in patients with septic shock*

Yasser Sakr, Marc‐Jacques Dubois, Daniel De Backer et al. · Critical Care Medicine · 2004 · 1.3K citations

Veterinary Medicine, Physiology, Biomedical Imaging +15

Microvascular perfusion is impaired in a rat model of normotensive sepsis.

C. Lam, Karel Tyml, Claudio M. Martin et al. · Journal of Clinical Investigation · 1994 · 360 citations · Full text

Veterinary Medicine, Physiology, Hematology Physiology +16

Effect of a maldistribution of microvascular blood flow on capillary O₂ extraction in sepsis

Christopher G. Ellis, Ryon M. Bateman, Michael D. Sharpe et al. · American Journal of Physiology-Heart and Circulatory Physiology · 2002 · 273 citations

Engineering, Physiology, Biological Transport Phenomena +16

Platelet Count Decline

Delphine Moreau, Jean-Fran ̧ois Timsit, Aurélien Vesin et al. · CHEST Journal · 2007 · 216 citations