Abnormal distribution of cathepsins in the brain of patients with Alzheimer's disease

Enzymatically active lysosomal proteases are associated with amyloid deposits in Alzheimer brain.

Anne M. Cataldo, Ralph A. Nixon · Proceedings of the National Academy of Sciences · 1990 · 443 citations

Life Sciences, Neurobiology, Neuroscience +17

Lysosomal proteinase antigens are prominently localized within senile plaques of Alzheimer's disease: evidence for a neuronal origin

Anne M. Cataldo, C.Y. Thayer, Edward D. Bird et al. · Brain Research · 1990 · 178 citations

Medicine, Neuroscience, Pathology +16

Lysosome instability in aged rat brain

Yu Nakamura, Masatoshi Takeda, Hideo Suzuki et al. · Neuroscience Letters · 1989 · 71 citations

Life Sciences, Neurobiology, Neuroscience +14

Breakdown of somatostatin and substance P by cathepsin D purified from calf brain by affinity chromotography

M. Benuck, Alice Grynbaum, Neville Marks · Brain Research · 1978 · 62 citations

Life Sciences, Biochemistry, Neuroscience +10

Immunocytochemical localization of cathepsin D in rat neural tissue

John N. Whitaker, L. Cass Terry, William O. Whetsell · Brain Research · 1981 · 58 citations

Medicine, Neurobiology, Neuroscience +8