Total Synthesis of Brevetoxin A: Part 1: First Generation Strategy and Construction of BCD Ring System

Abstract

Dissection of brevetoxin A at the nine-membered ring site (ring E) formed the basis of the first generation strategy for the total synthesis of this molecule. Unfortuately the planned hydroxy dithioketal cyclization to form the crucial nonacene did not proceed as anticipated and this approach was discontinued.