Concepedia

S -adenosyl methionine regulates ubiquitin-conjugating enzyme 9 protein expression and sumoylation in murine liver and human cancers

Maria Lauda Tomasi, Ivan Tomasi, Komal Ramani, Rosa M. Pascale, Jun Xu, Pasquale Giordano, José M. Mato, Shelly C. Lu

Hepatology · 2012 · 86 citations · 29 references

DOIFull text

Open access

Abstract

Cdc2 expression is increased and Ubc9 is hyperphosphorylated in several cancers, and this represents a novel mechanism to maintain high Ubc9 protein expression that can be inhibited by SAMe and MTA.

References

29

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The importance of intrinsic disorder for protein phosphorylation

Lilia M. Iakoucheva · Nucleic Acids Research · 2004 · 1.4K citations · Full text

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Betaine decreases hyperhomocysteinemia, endoplasmic reticulum stress, and liver injury in alcohol-fed mice

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Ubc9p Is the Conjugating Enzyme for the Ubiquitin-like Protein Smt3p

Erica S. Johnson, Günter Blobel · Journal of Biological Chemistry · 1997 · 495 citations · Full text

Methionine adenosyltransferase 1A knockout mice are predisposed to liver injury and exhibit increased expression of genes involved in proliferation

Shelly C. Lu, Luis Álvarez, Zong‐Zhi Huang et al. · Proceedings of the National Academy of Sciences · 2001 · 448 citations · Full text