Concepedia

Dopamine-Induced Conformational Changes in Alpha-Synuclein

Tiago F. Outeiro, Jochen Klucken, Kathryn K. Bercury, Julie E. Tetzlaff, Preeti Putcha, Luís M. A. Oliveira, Alexandre Quintas, Pamela J. McLean, Bradley T. Hyman

PLoS ONE · 2009 · 65 citations · 30 references

DOIFull text

Open access

Abstract

Our results show, for the first time, a direct effect of dopamine on the conformation of alpha-synuclein in neurons, which may help explain the increased vulnerability of dopaminergic neurons in Parkinson's disease.

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