Concepedia

Phytanic acid and pristanic acid, branched-chain fatty acids associated with Refsum disease and other inherited peroxisomal disorders, mediate intracellular Ca2+ signaling through activation of free fatty acid receptor GPR40

Nicol Kruska, Georg Reiser

Neurobiology of Disease · 2011 · 23 citations · 41 references

DOIFull text

Open access

Concepts

References

41

Free fatty acids regulate insulin secretion from pancreatic β cells through GPR40

Yasuaki Itoh, Yuji Kawamata, Masataka Harada et al. · Nature · 2003 · 1.5K citations

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The Orphan G Protein-coupled Receptor GPR40 Is Activated by Medium and Long Chain Fatty Acids

Celia P. Briscoe, Mohammad Tadayyon, John L. Andrews et al. · Journal of Biological Chemistry · 2003 · 1.1K citations · Full text

The FFA receptor GPR40 links hyperinsulinemia, hepatic steatosis, and impaired glucose homeostasis in mouse

Pär Steneberg, Nir Rubins, Reut Bartoov-Shifman et al. · Cell Metabolism · 2005 · 412 citations · Full text

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A human cell surface receptor activated by free fatty acids and thiazolidinedione drugs

Knut Kotarsky, Niclas Nilsson, Erik Flodgren et al. · Biochemical and Biophysical Research Communications · 2003 · 349 citations

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Oleic acid interacts with GPR40 to induce Ca<sup>2+</sup>signaling in rat islet β-cells: mediation by PLC and L-type Ca<sup>2+</sup>channel and link to insulin release

Ken Fujiwara, Fumihiko Maekawa, Toshihiko Yada · American Journal of Physiology-Endocrinology and Metabolism · 2005 · 250 citations