The age-dependent binding of CBP/tk, a ccaat binding protein, is deregulated in transformed and immortalized mammalian cells but absent in premature aging cells

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

Mark A. Bradford · Analytical Biochemistry · 1976 · 225.3K citations

Protein Chemistry, Biochemistry, Protein Folding +13

The serial cultivation of human diploid cell strains

Leonard Hayflick, Paul S. Moorhead · Experimental Cell Research · 1961 · 8.3K citations

Human Cell, Cell Division, Genetics +5

Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1.

Ralf Schreck, P. Rieber, Patrick A. Baeuerle · The EMBO Journal · 1991 · 3.8K citations · Full text

Inflammation, Cytokine, Transcriptional Regulation +13

Genetic Analysis with Man–Mouse Somatic Cell Hybrids: Linkage between Human Lactate Dehydrogenase B and Peptidase B Genes

A. SILVANA BENERECETTI SANTACHIARA, Markus Nabholz, V. Miggiano et al. · Nature · 1970 · 1.1K citations

Genetic Analysis, Developmental Biology, Somatic Variant +12

A multiplicity of CCAAT box-binding proteins

Arnulf Dorn, Jacques Bollekens, Adrian Staub et al. · Cell · 1987 · 745 citations

Protein Function, Signal Transduction, Protein Assembly +5