Concepedia

An improved synthesis of the unique anti-migraine agent CP-122,288: A bromine atom passenger in an intramolecular Heck reaction

John E. Macor, Ron Ogilvie, Martin Wythes

Tetrahedron Letters · 1996 · 40 citations · 4 references

Concepts

PharmacyChemistryMedicinal ChemistryNeuropharmacologyOrganic ChemistrySynthetic Medicinal ChemistryHeadache DisordersMigraine PharmacotherapyRetrosynthetic AnalysisBromine ActivationBromine ChemistryHeck ReactionMigraine Pharmacology

References

4

Palladium-catalyzed reactions in the synthesis of 3- and 4-substituted indoles. 2. Total synthesis of the N-acetyl methyl ester of (.+-.)-clavicipitic acids

Peter J. Harrington, Louis S. Hegedus, Keith F. McDaniel · Journal of the American Chemical Society · 1987 · 187 citations

Natural Sciences, Chemistry, Catalysis +11

Conformationally restricted sumatriptan analogues, CP-122,288 and CP-122,638 exhibit enhanced potency against neurogenic inflammation in dura mater

Won Suk Lee, Michael A. Moskowitz · Brain Research · 1993 · 70 citations

Medicine, Neuroscience, Pharmacology +9

The synthesis of a conformationally restricted analog of the anti-migraine drug sumatriptan

John E. Macor, David H.A. Blank, Ronald J. Post et al. · Tetrahedron Letters · 1992 · 45 citations

Pharmacy, Medicinal Chemistry, Pharmacology +9

Fluticasone propionate

Sussie Hopkins · Drugs of today · 1992 · 10 citations