Piperidine-derived γ-secretase modulators

A subset of NSAIDs lower amyloidogenic Aβ42 independently of cyclooxygenase activity

Sascha Weggen, Jason L. Eriksen, Pritam Das et al. · Nature · 2001 · 1.4K citations

Life Sciences, Neuroscience, Pharmacology +14

Nonsteroidal Antiinflammatory Drugs and the Risk of Alzheimer's Disease

Bas A. in 't Veld, Annemieke Ruitenberg, Albert Hofman et al. · New England Journal of Medicine · 2001 · 1.2K citations · Full text

Medicine, Pharmacology, Pharmacotherapy +14

Effects of rofecoxib or naproxen vs placebo on Alzheimer disease progression: a randomized controlled trial.

Paul Aisen, Kimberly Schafer, Michael Grundman et al. · PubMed · 2003 · 968 citations

Medicine, Pharmacology, Pharmacotherapy +17

Chronic Treatment with the γ-Secretase Inhibitor LY-411,575 Inhibits β-Amyloid Peptide Production and Alters Lymphopoiesis and Intestinal Cell Differentiation

Gwendolyn T. Wong, Denise Manfra, Frederique M. Poulet et al. · Journal of Biological Chemistry · 2004 · 716 citations · Full text

Life Sciences, Immunology, Pharmacology +17

Modulation of Notch Processing by γ-Secretase Inhibitors Causes Intestinal Goblet Cell Metaplasia and Induction of Genes Known to Specify Gut Secretory Lineage Differentiation

Joseph Milano, Jenny McKay, Claude Dagenais et al. · Toxicological Sciences · 2004 · 565 citations

Medicine, Medicinal Chemistry, Pharmacology +15