Synthesis of novel 1-, 1,4- and 1,7-substituted 2-mercapto- and 2-methylmercapto- benzimidazoles: Acyclic analogues of the HIV-1 RT inhibitor, TIBO

Crystal Structure at 3.5 Å Resolution of HIV-1 Reverse Transcriptase Complexed with an Inhibitor

Lori A. Kohlstaedt, J Wang, Jonathan M. Friedman et al. · Science · 1992 · 1.9K citations

Crystal Structure, Viral Replication, Active Sites +19

Chiral Aziridines—Their Synthesis and Use in Stereoselective Transformations

David Tanner · Angewandte Chemie International Edition in English · 1994 · 1.1K citations

Bioorganic Chemistry, Engineering, Chiral Aziridines—their Synthesis +11

Potent and selective inhibition of HIV-1 replication in vitro by a novel series of TIBO derivatives

Rudi Pauwels, Koen Andries, Jan Desmyter et al. · Nature · 1990 · 754 citations

Selective Inhibition, Medicinal Chemistry, Medicine +11

HIV inhibitory natural products. Part 7. The calanolides, a novel HIV-inhibitory class of coumarin derivatives from the tropical rainforest tree, Calophyllum lanigerum

Yoel Kashman, Kirk R. Gustafson, Ray W. Fuller et al. · Journal of Medicinal Chemistry · 1992 · 546 citations

High resolution structures of HIV-1 RT from four RT–inhibitor complexes

Jingshan Ren, Robert Esnouf, Elspeth F. Garman et al. · Nature Structural & Molecular Biology · 1995 · 498 citations

Biochemistry, Natural Sciences, Human Retrovirus +8