Involvement of phosphoinositide 3-kinase in insulin stimulation of MAP-kinase and phosphorylation of protein kinase-B in human skeletal muscle: implications for glucose metabolism

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

Darren A.E. Cross, Dario R. Alessi, Philip Cohen et al. · Nature · 1995 · 5.2K citations

Signal Transduction, Molecular Physiology, Biochemistry +10

A synthetic inhibitor of the mitogen-activated protein kinase cascade.

David T. Dudley, Long Pang, Stuart J. Decker et al. · Proceedings of the National Academy of Sciences · 1995 · 2.7K citations · Full text

Signal Transduction, Pd 098059, Cell Regulation +14

Phosphatidylinositol 3-Kinase Activation Is Required for Insulin Stimulation of pp70 S6 Kinase, DNA Synthesis, and Glucose Transporter Translocation

Bentley Cheatham, Chris J. Vlahos, Lynn Cheatham et al. · Molecular and Cellular Biology · 1994 · 1K citations · Full text

Phosphatidylinositol 3-Kinase, Insulin Signaling, Pp70 S6 Kinase +20

Essential role of phosphatidylinositol 3-kinase in insulin-induced glucose transport and antilipolysis in rat adipocytes. Studies with a selective inhibitor wortmannin.

Taro Okada, Y. Kawano, Tsuneki Sakakibara et al. · Journal of Biological Chemistry · 1994 · 918 citations · Full text

Insulin Receptor, Insulin Signaling, Molecular Pharmacology +19

Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation.

Bentley Cheatham, Chris J. Vlahos, L Cheatham et al. · Molecular and Cellular Biology · 1994 · 621 citations

Phosphatidylinositol 3-Kinase, Insulin Signaling, Pp70 S6 Kinase +21