Concepedia

Chromo-pharmacophores: photochromic diarylmaleimide inhibitors for sirtuins

Carolin Falenczyk, Matthias Schiedel, Berin Karaman, Tobias Rumpf, Natascha Kuzmanovic, Morten Grøtli, Wolfgang Sippl, Manfred Jung, Burkhard König

Chemical Science · 2014 · 56 citations · 24 references

DOIFull text

Open access

Concepts

Abstract

Controlling the activity of sirtuins is of high biomedical relevance as the enzymes are involved in cancer, neurodegeneration and other diseases.

References

24

The Human Sir2 Ortholog, SIRT2, Is an NAD+-Dependent Tubulin Deacetylase

Brian J. North, Brett Marshall, Margie T. Borra et al. · Molecular Cell · 2003 · 1.5K citations · Full text

, , +9

Photopharmacology: Beyond Proof of Principle

Willem A. Velema, Wiktor Szymański, Ben L. Feringa · Journal of the American Chemical Society · 2014 · 1.2K citations · Full text

, , +13

Sirtuin 2 Inhibitors Rescue α-Synuclein-Mediated Toxicity in Models of Parkinson's Disease

Tiago F. Outeiro, Eirene Kontopoulos, Stephen M. Altmann et al. · Science · 2007 · 1.1K citations · Full text

, , +17

A novel pathway regulates memory and plasticity via SIRT1 and miR-134

Jun Gao, Wen-Yuan Wang, Yingwei Mao et al. · Nature · 2010 · 979 citations · Full text

, , +12

SIRT Inhibitors Induce Cell Death and p53 Acetylation through Targeting Both SIRT1 and SIRT2

Barrie Peck, Chun‐Yuan Chen, Ka-Kei Ho et al. · Molecular Cancer Therapeutics · 2010 · 434 citations

, , +17