PLoS ONE · 2012 · 28 citations · 26 references
Veterinary MedicineImmunologyInfectious DiseasesImmunology Of Infectious DiseasesInflammationInnate ImmunityCellular Immune ResponsesInflammatory Cell ResponsesMacrophage BiologyMacrophage Responses To ParasitesMalariaPhagocyte BiologyInflammatory Cytokine ProductionInflammatory Cytokine SecretionMacrophage Cytokine ProductionMacrophage Inflammatory ResponsesMacrophage Phagocytosis Of ParasitesMalaria ImmunologyMonocyte-derived MacrophagesPhagocyte Activation
HIV-1 infection increases the risk and severity of malaria by poorly defined mechanisms. We investigated the effect of HIV-1(Ba-L) infection of monocyte-derived macrophages (MDM) on phagocytosis of opsonised P. falciparum infected erythrocytes (IE) and subsequent proinflammatory cytokine secretion. Compared to mock-infected MDM, HIV-1 infection significantly inhibited phagocytosis of IE (median (IQR) (10 (0-28) versus (34 (27-108); IE internalised/100 MDM; p = 0.001) and decreased secretion of IL-6 (1,116 (352-3,387) versus 1,552 (889-6,331); pg/mL; p = 0.0078) and IL-1β (16 (7-21) versus 33 (27-65); pg/mL; p = 0.0078). Thus inadequate phagocytosis and cytokine production may contribute to impaired control of malaria in HIV-1 infected individuals.
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The Impact of Placental Malaria on Gestational Age and Birth Weight
Clara Menéndez, Jaume Ordï, Mamudo R. Ismail et al. · The Journal of Infectious Diseases · 2000 · 469 citations
Feiko O. ter Kuile, Monica E. Parise, Francine H. Verhoeff et al. · American Journal of Tropical Medicine and Hygiene · 2004 · 371 citations