Concepedia

Antiangiogenic plasma activity in patients with systemic sclerosis

Mary Jo Mulligan‐Kehoe, Mary Drinane, Jessica Mollmark, Livia Casciola‐Rosen, Laura K. Hummers, Amy Hall, Antony Rosen, Fredrick M. Wigley, Michael Simons

Arthritis & Rheumatism · 2007 · 74 citations · 47 references

DOI

Abstract

Plasminogen conformation in patients with SSc enables granzyme B and granule content protease to limit the proangiogenic effects of plasmin and increase the levels of antiangiogenic angiostatin. This increase in angiostatin production may account for some of the vascular defects observed in patients with SSc.

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Angiostatin: A novel angiogenesis inhibitor that mediates the suppression of metastases by a lewis lung carcinoma

M. OʼReilly · Cell · 1994 · 3.3K citations

, , +9

Kinetics of the activation of plasminogen by human tissue plasminogen activator. Role of fibrin.

Marc Hoylaerts, D.C. Rijken, H.R. Lijnen et al. · Journal of Biological Chemistry · 1982 · 1.3K citations · Full text

Cleavage by Granzyme B Is Strongly Predictive of Autoantigen Status

Livia Casciola‐Rosen, Felipe Andrade, Danielle Ulanet et al. · The Journal of Experimental Medicine · 1999 · 486 citations · Full text

Tumstatin, an Endothelial Cell-Specific Inhibitor of Protein Synthesis

Yohei Maeshima, Akulapalli Sudhakar, Julie C. Lively et al. · Science · 2002 · 436 citations

, , +15