New 1-arylindoles based serotonin 5-HT7 antagonists. Synthesis and binding evaluation studies

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

Yung-Chi Cheng, William H. Prusoff · Biochemical Pharmacology · 1973 · 12.9K citations

Life Sciences, Biochemistry, Chemical Kinetics +14

Cloning of a novel human serotonin receptor (5-HT7) positively linked to adenylate cyclase.

Jonathan Bard, J M Zgombick, Nika Adham et al. · Journal of Biological Chemistry · 1993 · 529 citations · Full text

Life Sciences, Molecular Biology, Pharmacology +15

Functional Characterization of the Recombinant Human 5-Hydroxytryptamine7(a) Receptor Isoform Coupled to Adenylate Cyclase Stimulation

Nika Adham, John M. Zgombick, Jonathan Bard et al. · Journal of Pharmacology and Experimental Therapeutics · 1998 · 90 citations

Medicine, Pharmacology, Molecular Pharmacology +16

Receptor-Based Pharmacophores for Serotonin 5-HT₇R AntagonistsImplications to Selectivity

Marcin Kołaczkowski, Mateusz Nowak, Maciej Pawłowski et al. · Journal of Medicinal Chemistry · 2006 · 72 citations

Pharmacy, Medicinal Chemistry, Pharmacology +17

The influence of modifications in imide fragment structure on 5-HT1A and 5-HT7 receptor affinity and in vivo pharmacological properties of some new 1-(m-trifluoromethylphenyl)piperazines

Maria H. Paluchowska, Ryszard Bugno, Beata Duszyńska et al. · Bioorganic & Medicinal Chemistry · 2007 · 57 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +16