Immunofluorescent localization of immunoglobulins, complement, and fibrinogen in human diseases. II. Acute, subacute, and chronic glomerulonephritis.

Abstract

Gamma globulin and complement have been demonstrated in renal glomeruli of patients with glomerulonephritis (1-10). Certain problems, which are the subject of the present investigation, remain to be elucidated: 1) the type of immuno- globulin (y2, 71m, or yiA) present in the renal le- sion and its relation to complement localization; and 2) the significance of fibrinogen localization. Kidneys from patients with acute, subacute, and chronic glomerulonephritis were examined by the fluorescent antibody technique to assess the nature of protein deposition in the renal parenchyma.