Kinetics of desensitization and recovery from desensitization for human α4β2-nicotinic acetylcholine receptors stably expressed in SH-EP1 cells

A study of the ‘desensitization’ produced by acetylcholine at the motor end‐plate

B. Katz, S. Thesleff · The Journal of Physiology · 1957 · 1.5K citations

Medicine, Neurobiology, Neuroscience +14

A missense mutation in the neuronal nicotinic acetylcholine receptor α4 subunit is associated with autosomal dominant nocturnal frontal lobe epilepsy

Ortrud K. Steinlein, John C. Mulley, Peter Propping et al. · Nature Genetics · 1995 · 1.1K citations

Life Sciences, Neurology, Neuroscience +12

A subtype of nicotinic cholinergic receptor in rat brain is composed of alpha 4 and beta 2 subunits and is up-regulated by chronic nicotine treatment.

C M Flores, S W Rogers, L A Pabreza et al. · Molecular Pharmacology · 1992 · 875 citations

Life Sciences, Neuroscience, Pharmacology +17

Single acetylcholine-activated channels show burst-kinetics in presence of desensitizing concentrations of agonist

Bert Sakmann, Joseph B. Patlak, Erwin Neher · Nature · 1980 · 605 citations

Life Sciences, Neuroscience, Pharmacology +12

Evidence that Tobacco Smoking Increases the Density of (−)‐[³H]Nicotine Binding Sites in Human Brain

Maureen E.M. Benwell, David J.K. Balfour, John M. Anderson · Journal of Neurochemistry · 1988 · 552 citations

Life Sciences, Neurobiology, Neuroscience +14