Data Analysis and Graphics using R: an Example-based Approach

Abstract

mathematical models, discussing the interpretation of PK parameters.Compartment models and the distribution of drug concentration throughout the body are discussed in Chapter 5 and Chapter 6 briefly introduces pharmaco-dynamics (PD), the study of the effect of drugs, and PK-PD modelling, relating drug distribution to potency and toxicity.A real example from AstraZeneca is used to illustrate some of the methods, and good use is made of synthetic examples to explain concepts.There is a dearth of references, which makes further reading difficult and makes the text appear to be a very personal view of the subject.On occasion, clinical or biological terms are used without a full definition.Overall, the book provides a good introduction to some of the problems in the area of PK modelling to which statistical methods are now being routinely applied.