Interferon-α2b Secretion by Adenovirus-Mediated Gene Delivery in Rat, Rabbit, and Chimpanzee Results in Similar Pharmacokinetic Profiles

Cellular immunity to viral antigens limits E1-deleted adenoviruses for gene therapy.

Yang Yang, Frederick A. Nunes, Klára Berencsi et al. · Proceedings of the National Academy of Sciences · 1994 · 1.6K citations

Life Sciences, Immunology, Molecular Biology +15

Retrovirus–mediated wild–type P53 gene transfer to tumors of patients with lung cancer.

Jack A. Roth, Dao Nguyen, David Lawrence et al. · Nature Medicine · 1996 · 703 citations

Medicine, Molecular Genetics, Oncology +14

Gene delivery to skeletal muscle results in sustained expression and systemic delivery of a therapeutic protein

Paul Kessler, Gregory M. Podsakoff, Xiaojuan Chen et al. · Proceedings of the National Academy of Sciences · 1996 · 616 citations · Full text

Pharmacy, Bioengineering, Biotechnology +17

Persistent and therapeutic concentrations of human factor IX in mice after hepatic gene transfer of recombinant AAV vectors

Richard O. Snyder, Carol H. Miao, G. Patijn et al. · Nature Genetics · 1997 · 585 citations

Pharmacy, Genetics, Molecular Biology +13

Innate Immune Mechanisms Dominate Elimination of Adenoviral Vectors Following <i>In Vivo</i> Administration

Stefan Worgall, G. Wolff, Erik Falck-Pedersen et al. · Human Gene Therapy · 1997 · 496 citations

Life Sciences, Immunology, Molecular Biology +15