Effect of metformin treatment on insulin action in diabetic rats: In vivo and in vitro correlations

THE ATTRACTIONS OF PROTEINS FOR SMALL MOLECULES AND IONS

George Scatchard · Annals of the New York Academy of Sciences · 1949 · 19.9K citations

Protein Chemistry, Protein Function, Protein Assembly +5

The Effect of Insulin on the Disposal of Intravenous Glucose: Results from Indirect Calorimetry and Hepatic and Femoral Venous Catheterization

Ralph A. DeFronzo, E Jacot, E Jéquier et al. · Diabetes · 1981 · 1.8K citations

Muscle Tissue, Glucose Storage, Glucose Production +22

Effects of insulin on peripheral and splanchnic glucose metabolism in noninsulin-dependent (type II) diabetes mellitus.

Ralph A. DeFronzo, Rebeqa Gunnarsson, Ola Björkman et al. · Journal of Clinical Investigation · 1985 · 1.2K citations · Full text

Splanchnic Glucose Metabolism, Type Ii, Insulin Signaling +18

Replacement of insulin receptor tyrosine residues 1162 and 1163 compromises insulin-stimulated kinase activity and uptake of 2-deoxyglucose

Leland Ellis, Éric Clauser, David O. Morgan et al. · Cell · 1986 · 1.1K citations

Signal Transduction, Biochemistry, G Protein-coupled Receptor +9

Correction of hyperglycemia with phlorizin normalizes tissue sensitivity to insulin in diabetic rats.

Luciano Rossetti, Douglas J. Smith, Gerald I. Shulman et al. · Journal of Clinical Investigation · 1987 · 803 citations · Full text

Insulin Resistance, Metabolic Syndrome, Glucose Tolerance +15