A Nonimmunosuppressant FKBP-12 Ligand Increases Nerve Regeneration

Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

Jun S. Liu, Jesse D. Farmer, Willam S. Lane et al. · Cell · 1991 · 4.1K citations

Life Sciences, Biochemistry, Molecular Biology +8

Degeneration and Regeneration of the Nervous System.

JAMA · 1929 · 2.9K citations

Medicine, Neurology, Surgery +8

A receptor for the immuno-suppressant FK506 is a cis–trans peptidyl-prolyl isomerase

Matthew W. Harding, David Uehling, Stuart L. Schreiber · Nature · 1989 · 1.4K citations

Medicine, Immunology, Pharmacology +8

A cytosolic binding protein for the immunosuppressant FK506 has peptidyl-prolyl isomerase activity but is distinct from cyclophilin

John J. Siekierka, Shirley H.Y. Hung, Martin Poe et al. · Nature · 1989 · 1K citations

Life Sciences, Biochemistry, Pharmacology +9

Inhibition of T cell signaling by immunophilin-ligand complexes correlates with loss of calcineurin phosphatase activity

J. Liu, Mark W. Albers, Thomas J. Wandless et al. · Biochemistry · 1992 · 561 citations

Life Sciences, Biochemistry, Immunology +17