Lesson plan for protein exploration in a large biochemistry class*

Abstract

Abstract The teaching of structural concepts plays a prominent role in many chemistry and biology courses. When it comes to macromolecular systems, a thorough understanding of noncovalent interactions lays a strong foundation for students to understand such things as protein folding, the formation of protein‐ligand complexes, and the melting of the DNA double helix. The incorporation of computer‐based molecular graphics into the biochemistry curriculum has given students unique opportunities in visualizing the structure of biological molecules and recognizing the subtle aspects of noncovalent interactions. This report describes a series of visualization‐based assignments developed to facilitate protein exploration in a large biochemistry class. A large enrollment can present special challenges for students to benefit from hands‐on use of visualization software. Three of the assignments are described in detail along with a description of an on‐line teaching tool used to manage the assignments and to coordinate the student groups participating in these exercises.