Concepedia

Interferon Regulatory Factor-1 in Flagellin-Induced Reprogramming: Potential Protective Role of CXCL10 in Cornea Innate Defense Against<i>Pseudomonas aeruginosa</i>Infection

Gi Sang Yoon, Dong Chen, Nan Gao, Ashok Kumar, Theodore J. Standiford, Fu-Shin X. Yu

Investigative Ophthalmology & Visual Science · 2013 · 28 citations · 42 references

DOIFull text

Open access

Abstract

IRF1 plays a role in the corneal innate immune response by regulating CXCL10 expression. IFNγ-producing NK cells augment the epithelial expression of IRF1 and CXCL10 and thus contribute to the innate defense of the cornea against P. aeruginosa infection.

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