Metabolism of 11-oxygenated steroids. 1. Influence of the A/B ring junction on the reduction of 11-oxo groups

Abstract

of such animals to utilize glucose, with a consequent rise of gluconeogenesis in the liver. Such a possi- bility is supported by the observation of Ashmore, Hastings, Nesbett & Renold (1956) that the administration of insulin can restore the blood- sugar level of alloxan-diabetic rats to normal before any change in glucose 6-phosphatase activity can be detected. The observations re- corded in the present paper do not support the view that there need be any direct action of insulin on liver glucose 6-phosphatase.