Frequent detection of <scp><i>BRAF</i>^V</scp>^600E mutations in histiocytic and dendritic cell neoplasms

Abstract

BRAF(V600E) was not limited to LCH and was detected more frequently in histiocytic sarcoma. Our findings suggest that the BRAF pathway may contribute to the pathogenesis or malignant transformation of histiocytic and dendritic cell neoplasms.