Concepedia

A pharmacological model reveals biased dependency on PI3K isoforms for tumor cell growth

Xiang Wang, Jia-peng Li, Yan Yang, Jian Ding, Linghua Meng

Acta Pharmacologica Sinica · 2013 · 12 citations · 15 references

DOIFull text

Open access

Concepts

References

15

A Pharmacological Map of the PI3-K Family Defines a Role for p110α in Insulin Signaling

Zachary A. Knight, Beatriz González, Morri E. Feldman et al. · Cell · 2006 · 1.2K citations · Full text

, , +14

Blockade of PI3Kγ suppresses joint inflammation and damage in mouse models of rheumatoid arthritis

Montserrat Camps, Thomas Rückle, Hong Ji et al. · Nature Medicine · 2005 · 751 citations

, , +15

Essential roles of PI(3)K–p110β in cell growth, metabolism and tumorigenesis

Shidong Jia, Zhenning Liu, Sen Zhang et al. · Nature · 2008 · 684 citations · Full text

, , +16

A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma

Qi-Wen Fan, Zachary A. Knight, David Goldenberg et al. · Cancer Cell · 2006 · 584 citations · Full text

, , +10

Phosphatidylinositol 3-kinase-δ inhibitor CAL-101 shows promising preclinical activity in chronic lymphocytic leukemia by antagonizing intrinsic and extrinsic cellular survival signals

Sarah E. M. Herman, Amber Gordon, Amy J. Wagner et al. · Blood · 2010 · 541 citations · Full text

, , +16