Pharmacokinetics of Vancomycin in Extremely Obese Patients with Suspected or Confirmed <i><scp>S</scp>taphylococcus aureus</i> Infections

Abstract

Total body weight and Clcr influenced volume of distribution and vancomycin clearance, respectively. Vancomycin can be initiated in extremely obese patients at dosages determined based on renal function and pharmacokinetic parameter estimates from this study. Vancomycin serum concentrations should be monitored to ascertain attainment within the therapeutic range.