Journal of Natural Products · 2004 · 60 citations · 25 references
MedicineMedicinal ChemistryPharmacologyBiochemical PharmacologyIon Channel BiophysicsSynthetic Medicinal ChemistryIon Channel ModulationIon Channel PharmacologyIon Channel RegulationPotassium Channel BiophysicsSignal Transduction ChemistryIon Channel PharmacodynamicsIon Channel TargetingPotassium Channel BlockadePotassium Channel PharmacologyVoltage-gated ChannelsVoltage-gated Ion ChannelsVoltage-gated Potassium Channels
A series of stilbenoid analogues of resveratrol (trans-3,4',5-trihydroxystilbene) with a stilbenic or a bibenzylic skeleton have been prepared by partial synthesis from resveratrol and dihydroresveratrol. The synthesized compounds have been evaluated for their ability to modulate voltage-gated channels.
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