p53-independent inhibition of nitric oxide generation by cancer preventive interventions in ex vivo mouse peritoneal macrophages

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

Lawrence A. Donehower, Michele Harvey, Betty L. Slagle et al. · Nature · 1992 · 4.7K citations

Medicine, Cancer Biology, Molecular Genetics +14

Curcumin, an Anti-tumor Promoter and Anti-inflammatory Agent, Inhibits Induction of Nitric Oxide Synthase in Activated Macrophages

I. Brouet, Hayato Ohshima · Biochemical and Biophysical Research Communications · 1995 · 475 citations

Life Sciences, Immunology, Pharmacology +17

Nitric oxide-induced p53 accumulation and regulation of inducible nitric oxide synthase expression by wild-type p53.

Kathleen Forrester, Stefan Ambs, Shawn E. Lupold et al. · Proceedings of the National Academy of Sciences · 1996 · 468 citations

Life Sciences, Genetics, Molecular Biology +13

Protein oxidation associated with aging is reduced by dietary restriction of protein or calories.

Linda Youngman, J Y Park, B N Ames · Proceedings of the National Academy of Sciences · 1992 · 250 citations

Life Sciences, Biochemistry, Nutritional Sciences +17

Glucocorticoids inhibit the induction of nitric oxide synthase II by down-regulating cytokine-induced activity of transcription factor nuclear factor-kappa B.

Hartmut Kleinert, Christian Euchenhofer, Irmgard Ihrig‐Biedert et al. · Molecular Pharmacology · 1996 · 232 citations

Life Sciences, Molecular Biology, Pharmacology +15