Lipopolysaccharides Modulate Allergen-Specific Immune Regulation in a Murine Model of Mucosal Tolerance Induction

Abstract

Microbial LPS modulated mucosal tolerance by inducing allergen-specific IgG1 production and distinct effector CD4+ T cells with a mixed regulatory/Th1 phenotype. Organic dust components such as LPS might therefore be important immune modulators in naturally occurring or preventive allergen-specific tolerance induction.