Concepedia

Investigation of N-terminal glutamate cyclization of recombinant monoclonal antibody in formulation development

Lei Yu, A. O. Vizel’, Mary Beth Huff, M.W. Young, Richard L. Remmele, Bing He

Journal of Pharmaceutical and Biomedical Analysis · 2006 · 77 citations · 16 references

DOI

Concepts

References

16

Techniques in Protein Chemistry

Journal of the American Society for Mass Spectrometry · 1993 · 1.3K citations

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Identification of multiple sources of charge heterogeneity in a recombinant antibody

Reed J. Harris, Bruce Kabakoff, Frank Macchi et al. · Journal of Chromatography B Biomedical Sciences and Applications · 2001 · 503 citations

, , +16

Commercial manufacturing scale formulation and analytical characterization of therapeutic recombinant antibodies

Reed J. Harris, Steven J. Shire, Charles Winter · Drug Development Research · 2004 · 197 citations

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An enzyme(s) that converts glutaminyl-peptides into pyroglutamyl-peptides. Presence in pituitary, brain, adrenal medulla, and lymphocytes.

Walker H. Busby, G E Quackenbush, Jane H. Humm et al. · Journal of Biological Chemistry · 1987 · 186 citations · Full text

, , +15

Glutaminyl cyclases unfold glutamyl cyclase activity under mild acid conditions

Stephan Schilling, Torsten Hoffmann, Susanne Manhart et al. · FEBS Letters · 2004 · 175 citations · Full text

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