Direct Conversion of <i>N</i>-Methoxy-<i>N</i>-methylamides (Weinreb Amides) to Ketones via a Nonclassical Wittig Reaction

Abstract

[reaction: see text] N-Methoxy-N-methylamides (Weinreb amides) are converted efficiently into ketones by reaction with alkylidenetriphenylphosphoranes and in situ hydrolysis of the product.