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A highly selective ester hydrolase from Pseudomonas sp. for the enzymatic preparation of enantiomerically pure secondary alcohols; chiral auxiliaries in organic synthesis
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1988
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BiosynthesisEngineeringBiotransformationBiochemistryNatural SciencesBiocatalysisBiochemical EngineeringPseudomonas SpNatural Product BiosynthesisValuable Chiral AuxiliariesEnzymatic HydrolysisPure Secondary AlcoholsSelective Ester HydrolaseAsymmetric CatalysisEnzymatic ModificationEnantioselective SynthesisBiomolecular EngineeringNatural Product Synthesis
A series of valuable chiral auxiliaries, (R)- and (S)-(1)–(11), have been prepared in high chemical and optical yields by enzymatic hydrolysis of their esters in the presence of a lipase from Pseudomonas sp.