Lipopolysaccharide‐induced expression of multiple alternatively spliced <i>MEFV</i> transcripts in human synovial fibroblasts: A prominent splice isoform lacks the C‐terminal domain that is highly mutated in familial mediterranean fever

Abstract

Several MEFV transcripts are expressed and inducible in synovial fibroblasts. A prominent isoform lacks the C-terminal domain that contains the majority of mutations found in patients with FMF. While recombinant forms of all major pyrin isoforms are cytoplasmic, native pyrin is nuclear in several cell types. Thus, mechanisms in addition to splicing patterns must control pyrin's subcellular distribution.