Concepedia

Betulinic acid as new activator of NF-κB: molecular mechanisms and implications for cancer therapy

Hubert Kasperczyk, Katia La Ferla-Brühl, Mike‐Andrew Westhoff, Lars Behrend, Ralf M. Zwacka, Klaus‐Michael Debatin, Simone Fulda

Oncogene · 2005 · 145 citations · 18 references

DOI

Concepts

References

18

Discovery of betulinic acid as a selective inhibitor of human melanoma that functions by induction of apoptosis

Emily Pisha, Heebyung Chai, Ik‐Soo Lee et al. · Nature Medicine · 1995 · 886 citations

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Sulfasalazine: a potent and specific inhibitor of nuclear factor kappa B.

Claudia Wahl, Susanne Liptay, G. Adler et al. · Journal of Clinical Investigation · 1998 · 740 citations · Full text

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Selective cytotoxicity of betulinic acid on tumor cell lines, but not on normal cells

Valentina Zuco, Rosanna Supino, Sabina Carla Righetti et al. · Cancer Letters · 2002 · 530 citations

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Active Repression of Antiapoptotic Gene Expression by RelA(p65) NF-κB

Kirsteen J. Campbell, Sónia Rocha, Neil D. Perkins · Molecular Cell · 2004 · 386 citations · Full text

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Activation of Mitochondria and Release of Mitochondrial Apoptogenic Factors by Betulinic Acid

Simone Fulda, Carsten Scaffidi, Santos A. Susín et al. · Journal of Biological Chemistry · 1998 · 374 citations · Full text

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