Publication | Closed Access
Cross-Linking of DNA in Situ as a Probe for Chromatin Structure
177
Citations
29
References
1976
Year
DnaGeneticsDna AnalysisMolecular BiologyPhotochemical Cross-linkingEpigeneticsElectron MicroscopyDna ReplicationChromatin RevealsChromatin BiologyNuclear OrganizationChromosomal RearrangementChromatin FunctionChromatinChromatin StructureChromatin RemodelingNatural SciencesEpigenomicsChromosome BiologyMedicine
The photochemical cross-linking of DNA in situ in chromatin is blocked over short intervals. Electron microscopy of DNA cross-linked in chromatin reveals the lengths of protected regions and provides a map of their sites along the DNA. Protected regions occur most frequently in tandem and have a basic length of 160 to 200 base pairs.
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