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Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

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Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death

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Inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia is caused by mutant valosin-containing protein

Giles D. Watts, Jill Wymer, Margaret J. Kovach et al. · Nature Genetics · 2004 · 1.4K citations · Full text

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