SSR182289A, a selective and potent orally active thrombin inhibitor

A convenient synthesis of acetylenes: catalytic substitutions of acetylenic hydrogen with bromoalkenes, iodoarenes and bromopyridines

Kenkichi Sonogashira, Yasuo Tohda, Nobue Hagihara · Tetrahedron Letters · 1975 · 5.1K citations

Chemical Engineering, Catalytic Substitutions, Engineering +8

The Palladium-Catalyzed Cross-Coupling Reaction of Phenylboronic Acid with Haloarenes in the Presence of Bases

Norio Miyaura, Teiji Yanagi, Atsushi Suzuki · Synthetic Communications · 1981 · 1.9K citations · Full text

Transition Metal-catalyzed Reactions, Chemical Engineering, Cross-coupling Reaction +11

The refined 1.9 A crystal structure of human alpha-thrombin: interaction with D-Phe-Pro-Arg chloromethylketone and significance of the Tyr-Pro-Pro-Trp insertion segment.

Wolfram Bode, Irmgard Mayr, Ulrich Baumann et al. · The EMBO Journal · 1989 · 890 citations · Full text

Protein Function, A Crystal Structure, Biochemistry +5

The refined 1.9‐Å X‐ray crystal structure of d‐Phe‐Pro‐Arg chloromethylketone‐inhibited human <i>α</i>‐thrombin: Structure analysis, overall structure, electrostatic properties, detailed active‐site geometry, and structure‐function relationships

Wolfram Bode, Andrej Karshikov · Protein Science · 1992 · 623 citations · Full text

Synthetic studies via the cross-coupling reaction of organoboron derivatives with organic halides

Akira Suzuki · Pure and Applied Chemistry · 1991 · 436 citations · Full text

Organoboron Derivatives, Cross-coupling Reaction, Engineering +6