Aldehyde dehydrogenase activity in leukemic blasts defines a subgroup of acute myeloid leukemia with adverse prognosis and superior NOD/SCID engrafting potential

Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell

Dominique Bonnet, John E. Dick · Nature Medicine · 1997 · 6.9K citations

Medicine, Hematology, Oncology +14

A cell initiating human acute myeloid leukaemia after transplantation into SCID mice

Tsvee Lapidot, Christian Sirard, Josef Vormoor et al. · Nature · 1994 · 4.7K citations

Medicine, Cell Biology, Hematology +14

Identification of the haematopoietic stem cell niche and control of the niche size

Jiwang Zhang, Chao Niu, Ling Ye et al. · Nature · 2003 · 2.9K citations · Full text

Life Sciences, Cell Biology, Hematology +14

Acute myeloid leukemia originates from a hierarchy of leukemic stem cell classes that differ in self-renewal capacity

Kristin J. Hope, Liqing Jin, John E. Dick · Nature Immunology · 2004 · 974 citations

Medicine, Cancer Biology, Oncology +16

Isolation of primitive human hematopoietic progenitors on the basis of aldehyde dehydrogenase activity

Robert W. Storms, Aliana P. Trujillo, James B. Springer et al. · Proceedings of the National Academy of Sciences · 1999 · 537 citations

Life Sciences, Cell Biology, Hematology +17