Evolution-related amino acids play important role in determining regioselectivity of fatty acid desaturase from Pichia pastoris

Eight Histidine Residues Are Catalytically Essential in a Membrane-Associated Iron Enzyme, Stearoyl-CoA Desaturase, and Are Conserved in Alkane Hydroxylase and Xylene Monooxygenase

John Shanklin, Edward Whittle, Brian G. Fox · Biochemistry · 1994 · 765 citations

The OLE1 gene of Saccharomyces cerevisiae encodes the delta 9 fatty acid desaturase and can be functionally replaced by the rat stearoyl-CoA desaturase gene

Joseph Stukey, Virginia McDonough, Charles E. Martin · Journal of Biological Chemistry · 1990 · 417 citations · Full text

Biosynthesis, Biochemistry, Fatty Acid Desaturase +12

Cloning of Higher Plant [omega]-3 Fatty Acid Desaturases

Narendra Singh Yadav, Anna Wierzbicki, M Aegerter et al. · PLANT PHYSIOLOGY · 1993 · 268 citations · Full text

Catalytic Plasticity of Fatty Acid Modification Enzymes Underlying Chemical Diversity of Plant Lipids

Pierre Broun, John Shanklin, Ed Whittle et al. · Science · 1998 · 260 citations

Plant Physiology, Engineering, Botany +16

Identification of a Δ4 Fatty Acid Desaturase fromThraustochytrium sp. Involved in the Biosynthesis of Docosahexanoic Acid by Heterologous Expression inSaccharomyces cerevisiae and Brassica juncea

Xiao Qiu, Haiping Hong, S. L. MacKenzie · Journal of Biological Chemistry · 2001 · 233 citations · Full text