Detection of single-base mutations in a mixed population of cells: A comparison of SSCP and direct sequencing

Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA Polymerase

Randall K. Saiki, David H. Gelfand, Susanne Stoffel et al. · Science · 1988 · 17.2K citations

Life Sciences, Biotechnology, Molecular Biology +12

Rapid and sensitive detection of point mutations and DNA polymorphisms using the polymerase chain reaction

Masato Orita, Youichi Suzuki, Takao Sekiya et al. · Genomics · 1989 · 3.5K citations

Life Sciences, Genetics, Molecular Genetics +16

Chromosome 17 Deletions and p53 Gene Mutations in Colorectal Carcinomas

Suzanne J. Baker, Eric R. Fearon, Janice Nigro et al. · Science · 1989 · 2.1K citations

Life Sciences, Genetics, Oncology +16

Mutational hot spot in the p53 gene in human hepatocellular carcinomas

Ih‐Chang Hsu, Robert A. Metcalf, Tai‐ping Sun et al. · Nature · 1991 · 1.5K citations

Medicine, Genetics, Oncology +16

Selective G to T mutations of p53 gene in hepatocellular carcinoma from southern Africa

Brigitte Bressac–de Paillerets, Michael C. Kew, Jack R. Wands et al. · Nature · 1991 · 1.4K citations

Medicine, Genetics, Oncology +16