Modulation of <scp>IL</scp>‐33/<scp>ST</scp>2 system in postinfarction heart failure: correlation with cardiac remodelling markers

Abstract

After AMI, expression of sST2 is rapidly upregulated during the first 4 weeks and, in contrast to IL-33, its levels correlated with the ongoing processes of fibrosis and inflammation. These findings suggest differential regulation of IL33 and sST2. Therapeutic modulation of early sST2 expression may be of greater importance to prevent adverse remodelling after AMI.