In vitro and in vivo profiling of fadolmidine, a novel potent α2-adrenoceptor agonist with local mode of action

Evidence that locus coeruleus is the site where clonidine and drugs acting at α₁‐ and α₂‐adrenoceptors affect sleep and arousal mechanisms

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Medicine, Neuroscience, Pharmacology +17

Pharmacological characteristics of alpha 2-adrenergic receptors: comparison of pharmacologically defined subtypes with subtypes identified by molecular cloning.

Dan Bylund, Howard S. Blaxall, L J Iversen et al. · Molecular Pharmacology · 1992 · 208 citations · Full text

Medicine, Biochemistry, Pharmacology +13

Pharmacokinetics and Pharmacodynamics of Intraspinal Dexmedetomidine in Sheep

James C. Eisenach, Steven L. Shafer, Brenda A. Bucklin et al. · Anesthesiology · 1994 · 129 citations · Full text

Medicine, Pharmacokinetics, Pharmacology +15

A cholinergic interaction in alpha 2 adrenoceptor-mediated antinociception in sheep.

Dawn J. Detweiler, James C. Eisenach, C. Tong et al. · Journal of Pharmacology and Experimental Therapeutics · 1993 · 120 citations

Medicine, Neurobiology, Pharmacology +16

α₂‐Adrenoceptor‐mediated potassium currents in acutely dissociated rat locus coeruleus neurones

Junichi Arima, Chiharu Kubo, Hitoshi Ishibashi et al. · The Journal of Physiology · 1998 · 92 citations · Full text

Life Sciences, Neuroscience, Pharmacology +16