The PTEN and INK4A/ARF tumor suppressors maintain myelolymphoid homeostasis and cooperate to constrain histiocytic sarcoma development in humans

Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands.

James G. Herman, Jeremy R. Graff, Sanna Myöhänen et al. · Proceedings of the National Academy of Sciences · 1996 · 5.6K citations · Full text

Epigenetic Change, Genetics, Dna Methylation +21

<i>PTEN</i> , a Putative Protein Tyrosine Phosphatase Gene Mutated in Human Brain, Breast, and Prostate Cancer

Jing Li, Clifford Yen, Danny Liaw et al. · Science · 1997 · 4.8K citations

World Health Organization Classification of Tumours: Pathology and Genetics of Tumours of Haematopoietic and Lymphoid Tissues

D. K. Hossfeld · Annals of Oncology · 2002 · 4.6K citations · Full text

Hematological Malignancy, Lymphoid Neoplasia, Tumoral Pathology +11

Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

Peter A. Steck, Mark A. Pershouse, Samar A. Jasser et al. · Nature Genetics · 1997 · 2.8K citations

Multiple Advanced Cancers, Tumor Biology, Chromosome 10Q23.3 +10

PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients

Yoichi Nagata, Keng‐Hsueh Lan, Xiaoyan Zhou et al. · Cancer Cell · 2004 · 1.8K citations · Full text

Trastuzumab Resistance, Pten Activation Contributes, Medicine +12