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The first reported generation of several induced pluripotent stem cell lines from homozygous and heterozygous Huntington's disease patients demonstrates mutation related enhanced lysosomal activity

Genome InstabilityHeterozygous HuntingtonInduced Pluripotent Stem CellGenetic DisorderMedicineGeneticsEnhanced Lysosomal ActivityMolecular GeneticsDisease PatientsChromosomal RearrangementStem CellsCell BiologyEpigeneticsLysosomal Storage DiseaseEmbryonic Stem Cell