Reversal of nitroglycerin tolerance in vitro by the cGMP-phosphodiesterase inhibitor zaprinast

Mechanism of vascular smooth muscle relaxation by organic nitrates, nitrites, nitroprusside and nitric oxide: evidence for the involvement of S-nitrosothiols as active intermediates.

L J Ignarro, Howard Lippton, Jo C. W. Edwards et al. · Journal of Pharmacology and Experimental Therapeutics · 1981 · 1.6K citations

Life Sciences, Biophysics, Physiology +6

MECHANISM OF TOLERANCE DEVELOPMENT TO ORGANIC NITRATES

Philip Needleman, Eugene M. Johnson · Journal of Pharmacology and Experimental Therapeutics · 1973 · 499 citations

Life Sciences, Biochemistry, Physiology +10

Oral Isosorbide dinitrate in angina pectoris: Comparison of duration of action and dose-response relation during acute and sustained therapy

Udho Thadani, Ho‐Leung Fung, Andrew C. Darke et al. · The American Journal of Cardiology · 1982 · 300 citations

Medicine, Cardiology, Pharmacology +9

Desensitization to nitroglycerin in vascular smooth muscle from rat and human

Scott A. Waldman, Robert M. Rapoport, Robert Ginsburg et al. · Biochemical Pharmacology · 1986 · 154 citations

Medicine, Pharmacology, Physiology +11

Tolerance towards nitroglycerin, induced in vivo, is correlated to a reduced cGMP response and an alteration in cGMP turnover

Krister L. Axelsson, Rolf G. G. Andersson · European Journal of Pharmacology · 1983 · 140 citations

Life Sciences, Pharmacology, Physiology +13