Concepedia

Molecular docking to understand the metabolic behavior of GNF-351 by CYP3A4 and its potential drug–drug interaction with ketoconazole

Tao Liu, Qian Ge, WenTing Wang, Yanguo Zhang

European Journal of Drug Metabolism and Pharmacokinetics · 2014 · 18 citations · 12 references

DOI

Concepts

References

12

Natural agonists for aryl hydrocarbon receptor in culture medium are essential for optimal differentiation of Th17 T cells

Marc Veldhoen, Keiji Hirota, Jillian R. Christensen et al. · The Journal of Experimental Medicine · 2008 · 521 citations · Full text

, , +17

The Pharmacokinetics, Metabolism, and Clearance Mechanisms of Tofacitinib, a Janus Kinase Inhibitor, in Humans

Martin E. Dowty, Jinyan Lin, Tim F. Ryder et al. · Drug Metabolism and Disposition · 2014 · 274 citations

, , +12

Therapeutic Role of Rifaximin in Inflammatory Bowel Disease: Clinical Implication of Human Pregnane X Receptor Activation

Jie Cheng, Yatrik M. Shah, Xiaochao Ma et al. · Journal of Pharmacology and Experimental Therapeutics · 2010 · 160 citations · Full text

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Rifaximin Is a Gut-Specific Human Pregnane X Receptor Activator

Xiaochao Ma, Yatrik M. Shah, Grace L. Guo et al. · Journal of Pharmacology and Experimental Therapeutics · 2007 · 120 citations

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Cytochrome P450 3A4 Inhibition by Ketoconazole: Tackling the Problem of Ligand Cooperativity Using Molecular Dynamics Simulations and Free-Energy Calculations

Urban Bren, Chris Oostenbrink · Journal of Chemical Information and Modeling · 2012 · 87 citations

, , +17